Solving Structures from Cell-Grown Crystals

Growing protein crystals can be a major challenge. Now, new crystallographic tools and methods can help us solve structures from nano-scale protein crystals. We are developing new approaches to growing and screening tiny crystals so that we can take full advantage of the available tools.

New Substrates for X-ray and Electron Diffraction

We are developing new substrates for diffraction and crystallography experiments: graphene-based structures are low background solutions for the support of crystalline and living samples under a variety of conditions. At left, crystals are shown sealed within a sheet of graphene paper. At right, we see a sheet that covers a TEM grid is transparent to 10 keV electrons.