Investigating Amyloid Structure & Function
Investigating disease-associated amyloids
The amyloid state of protein structure is associated with a number of systemic and neurodegenerative disorders including Alzheimer's and Parkinson's. The structures of amyloid fibrils have helped clarify fundamental aspects of these diseases and provide opportunities for the development of new therapies.
Functional amyloids & prions: Decoding structure-based amyloid functions
Prion is a state of protein folding. By studying the prion state, we can learn how proteins encode and transfer information. Importantly, not all prions & amyloids drive disease. We investigate prions & amyloids that may be associated with evolved biological functions including translational regulation, and learning and memory.
